Manitoba HIV Research Group University of Manitoba


Elevation of immune activation in kenyan women is associated with alterations in immune function: implications for vaccine development. J Clin Immunol. Koesters SA, Matu L, Kiama P, Anzala O, Embree J, Plummer FA, Kimani J, Fowke KR. 2004 Nov;24(6):702-9. PMID: 15622455

CD4+ T cell responses in HIV-exposed seronegative women are qualitatively distinct from those in HIV-infected women. J Infect Dis. Alimonti JB, Koesters SA, Kimani J, Matu L, Wachihi C, Plummer FA, Fowke KR. 2005 Jan 1;191(1):20-4. Epub 2004 Dec 1. PMID: 15592998

Construction of an infectious HIV type 1 molecular clone from an African patient with a subtype D/C Recombinant Virus. Shi B, Philpott SM, Weiser B, Kuiken C, Brunner C, Fang G, Fowke KR, Plummer FA, Rowland-Jones S, Bwayo J, Anzala AO, Kimani J, Kaul R, Burger H. AIDS Res Hum Retroviruses. 2004 Sep;20(9):1015-8. PMID: 15585089

HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers: a prospective analysis. AIDS. Kaul R, Rutherford J, Rowland-Jones SL, Kimani J, Onyango JI, Fowke K, MacDonald K, Bwayo JJ, McMichael AJ, Plummer FA. 2004 Oct 21;18(15):2087-9. PMID: 15577632

Novel interferon regulatory factor-1 polymorphisms in a Kenyan population revealed by complete gene sequencing. J Hum Genet. Ji H, Ball TB, Kimani J, Plummer FA. 2004;49(10):528-35. Epub 2004 Sep 17. PMID: 15378396

Antigen-specific gene expression profiles of peripheral blood mononuclear cells do not reflect those of T-lymphocyte subsets. Clin Diagn Lab Immunol. McLaren PJ, Mayne M, Rosser S, Moffatt T, Becker KG, Plummer FA, Fowke KR. 2004 Sep;11(5):977-82. PMID: 15358662

Characterization of protein-protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus. Virus Res. He R, Leeson A, Ballantine M, Andonov A, Baker L, Dobie F, Li Y, Bastien N, Feldmann H, Strocher U, Theriault S, Cutts T, Cao J, Booth TF, Plummer FA, Tyler S, Li X. 2004 Oct;105(2):121-5. PMID: 15351485

Identification of a novel HLA-DQA1 null allele, DQA1*0403N, from an East African woman. Tissue Antigens. Luo M, Cohen CR, Narayansingh MJ, Pan S, McKinnon L, Brunham RC, Plummer FA. 2004 Jun;63(6):609-11. PMID:15140045

Analysis of multimerization of the SARS coronavirus nucleocapsid protein. Biochem Biophys Res Commun. He R, Dobie F, Ballantine M, Leeson A, Li Y, Bastien N, Cutts T, Andonov A, Cao J, Booth TF, Plummer FA, Tyler S, Baker L, Li X. 2004 Apr 2;316(2):476-83. PMID: 15020242

CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion. Mayne M, Moffatt T, Kong H, McLaren PJ, FOWKE KR, Becker KG, Namaka M, Schenck A, Bardoni B, Bernstein CN, Melanson M. European Journal of Immunology 2004 34:1217-27. PMID: 15048733

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High resolution sequence-based DPB1 typing identified two novel DPB1 alleles, DPB1*9401 and DPB1*9501, from a Kenyan population. Tissue Antigens. Luo M, Ramdahin S, Iqbal S, Pan Y, Jacobson K, Narayansingh MJ, Schroeder M, Brunham RC, Embree J, Plummer FA. 2003 Aug;62(2):182-4. PMID: 12890000

Development of functional human monoclonal single-chain variable fragment antibody against HIV-1 from human cervical B cells. Hybrid Hybridomics. Berry JD, Rutherford J, Silverman GJ, Kaul R, Elia M, Gobuty S, Fuller R, Plummer FA, Barbas CF 3rd. 2003 Apr;22(2):97-108. PMID: 12831535

Quantitative ex vivo analysis of functional virus-specific CD8 T lymphocytes in the blood and genital tract of HIV-infected women. AIDS. Kaul R, Thottingal P, Kimani J, Kiama P, Waigwa CW, Bwayo JJ, Plummer FA, Rowland-Jones SL. 2003 May 23;17(8):1139-44. PMID: 12819514

Improved mRNA quantitation in LightCycler RT-PCR. Int Arch Allergy Immunol. Ball TB, Plummer FA, HayGlass KT. 2003 Jan;130(1):82-6. PMID: 12576739

Mechanisms of CD4+ T Lymphocyte Cell Death in HIV/AIDS. J. Gen Virol. Alimonti JB*, Ball TB and Fowke KR. 2003; 84: 1649-1661 and JGV Direct on-line publication. PMID:12810858

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HLA typing in a Kenyan cohort identifies novel class I alleles that restrict cytotoxic T-cell responses to local HIV-1 clades  Thomas G.Birda,and Francis A.Plummerb,et al. AIDS. 2002 Sep 27;16(14):1899-904. PIMD:12351949

Development of a novel allo-independent HIV-1 virus preparation for use in immunoassays  Sandra Koesters, W. John Rutherford, Keith R. Fowke* J Immunol Methods. PMID:12191511

Gonococcal Cervicitis Is Associated with Reduced Systemic CD8+ T Cell Responses in Human Immunodeficiency Virus Type 1–Infected and Exposed, Uninfected Sex Workers Rupert Kaul,and Francis A. Plummer, et al. J Infect Dis. 2002 May 15;185(10):1525-9.  PIMD:11992292

Modelling HIV/AIDS epidemics in Botswana and India:impact of interventions to prevent transmission  Nico J.D. Nagelkerke,and Frank A. Plummer, et al. Bull World Health Organ. PMID:11953786

Mother-to-child HIV transmission and ARVs. Science. de Vlas SJ, Nagelkerke NJ, Jha P, Plummer FA. 2002 Dec 13;298(5601):2129. PMID:12481779

HLA-A and HLA-B in Kenya, Africa: allele frequencies and identification of HLA-B*1567 and HLA-B*4426. Tissue Antigens. Luo M, Embree J, Ramdahin S, Ndinya-Achola J, Njenga S, Bwayo JB, Pan S, Mao X, Cheang M, Stuart T, Brunham RC, Plummer FA. 2002 May;59(5):370-80. PMID:12144620

Response of a sexually transmitted infection epidemic to a treatment and prevention programme in Nairobi, Kenya. Moses S, Ngugi EN, Costigan A, Kariuki C, Maclean I, Brunham RC, Plummer FA. Sex Transm Infect. 2002 Apr;78 Suppl 1:i114-20. PMID: 12083429

Reduced HIV risk-taking and low HIV incidence after enrollment and risk-reduction counseling in a sexually transmitted disease prevention trila in Nairobi, Kenya. Kaul R, Kmani J, Nagelkerke NJ, Fonck K, Keli F, MacDonald KS, Ronald AR, Plummer FA, Bwayo JJ, Ngugi EN, Temmerman M, Moses S. J Acquir Immune Defic Syndr. 2002 May 1;30(1):69-72. PMID: 12083429

Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57. gillespie GM, Kaul R, Dong T, Yang HB, Rostron T, Bwayo JJ, Kiama P, Peto T, Plummer FA, McMichael AJ, Rowland-Jones SL. AIDS. 2002 May 3;16(7):961-72. PMID: 12083429

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Male circumcision and HIV prevention: current kenowledge and future research directions Bailey RC, Plummer FA, Moses S. Lance Infect Dis. 2001 Nov;1(4):223-31. PMID:11595284

How important is the ‘quality’ of the cytotoxic T lymphocyte(CTL) response in protection against HIV infection? Sarah L.Francis A. Plummer, and Andrew McMichael, et al. Immunol Lett. 2001 Nov 1;79(1-2)1:15-20. PMID:11595285

How important is the ‘quality’ of the cytotoxic T lymphocyte(CTL) response in protection against HIV infection? Sarah L.Francis A. Plummer, and Andrew McMichael, et al. Immunol Lett. 2001 Nov 1;79(1-2)1:15-20. PMID:11595285

Human leucocyte antigen supertypes and immune susceptibility to HIV-1, implications for vaccine design Kelly S, and Francis A. Plummer, et al. Immunol Lett. 2001 Nov 1;79(1-2):151-7. PMID:11595302

Resistance to HIV-1 infection among African sex workers is associated with global hyporesponsiveness in interleukin 4 production1 HARSHA N, F. A. PLUMMER, and K. T. HAYGLASS*. FASEB J. 2001 Aug;15(10):1795-7. PMID:11481233

CD8+ lymphocytes respond to different HIV epitopes in seronegative and infected subjects Rupert Kaul, Francis A. Plummer, and Sarah L. Rowland-Jones, et al. J Clin Invest. 2001 May;107(10):1303-10. PMID:11375420

Late seroconversion in HIV-resistant Nairobi prostitutes despite pre-existing HIV-specific CD8+ responses Rupert Kaul, and Francis A. Plummer, et al. J Clin Invest. 2001 Feb;107(3):341-9. PMID:11160158

The HLA A2/6802 Supertype Is Associated with Reduced Risk of Perinatal Human Immunodeficiency Virus Type 1 Transmission Kelly S. MacDonald, and Francis A. Plummer, et al. J Clin Invest. 2001 Feb 1;183(3):503-6. PMID:11133384

Public health. Reducing HIV transmission in developing countries. Science. Jha P, Nagelkerke JD, Ngugi EN, Prasada Rao JV, Willbond B, Moses S, Plummer FA. 2001 Apr 13;292(5515):224-5. PMID: 11305312

Vitamin A and risk of HIV-1 seroconversion among Kenyan men with genital ulcers. AIDS. MacDonald KS, Malonza I, Chen DK, Nagelkerke NJ, Nasio JM, Ndinya-Achola J, Bwayo JJ, Sitar DS, Aoki FY, Plummer FA. 2001 Mar 30;15(5):635-9. PMID: 11317002

Sequence and peptide-binding motif for a variant of HLA-A*0214 (A*02142) in an HIV-1-resistant individual from the Nairobi Sex Worker cohort.. Luscher MA, MacDonald KS, Bwayo JJ, Plummer FA, Barber BH. Immunogentics. 2001 Feb;53(1):10-4. PMID: 11317002

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Reducing HIV-1 in Kenya and Tanzania Stephen Moses, Francis A Plummer, and Nico J D Nagelkerke. Lancet. 2000 Nov 4;356(9241):1602-3. PMID:11075790

Risk factors for postnatal motherąchild transmissionof HIV-1 Joanne E. Embree,and Francis A. Plummer, et al. AIDS. 2000 Nov 10;14(16):2535-41. PMID:11101065

Sociodemographic characteristics, care, feeding practices, and growth of cohorts of children born toHIV 1seropositive and seronegative mothers inNairobi,Kenya Bettylou Sherry1, Joanne E.Embree and Francis A.Plummer, et al. Trop Med Int Health. 2000 Oct;5(10):678-86. PMID:11044261

Acute Sexually Transmitted Infections Increase Human Immunodeficiency Virus Type 1 Plasma Viremia, Increase Plasma Type 2 Cytokines, and Decrease CD4 Cell Counts
Aggrey O. Anzala,and Francis A. Plummer,et al. J Infect Dis. 2000 Aug;182(2):459-66. PMID:10915076

Influence of HLA Supertypes on Susceptibility and Resistance to Human Immunodeficiency Virus Type 1 Infection Kelly S. MacDonald, Keith R. Fowke,and Francis A. Plummer,et al. J Infect Dis. 2000 May;181(5):1581-9. PMID:10823757

HIV-1-specific cellular immune responses among HIV-1-resistant sex workers Keith.R.Fowke, and Francis A Plummer,,et al. Immunol Cell Biol. 2000 Dec;78(6):586-95.  PIMD:11114968

Effect of Human Immunodeficiency Virus (HIV) Type 1 Viral Genotype on Mother-to-Child Transmission of HIV-1 Melanie C. M. Murray,Joanne E. Embree,,and Francis A. Plummer, et al. J Infect Dis. 200 Feb;181(2):746-9. PMID:10669368

HIV-1-Specific Mucosal CD8+ Lymphocyte Responses in the Cervix of HIV-1-Resistant Prostitutes in Nairobi Rupert Kaul, Francis A. Plummer, and L. Rowland-Jones†. J Immunol. 200 Feb 1;164(3):1602-11. PMID:10640781

A randomized, placebo-controlled trial of monthly azithromycin prophylaxis to prevent sexually transmitted infections and HIV-1 in Kenyan sex workers: study design and baseline findings. Fonck K, Kaul R, Kimani J, Keli F, MacDonald KS, Ronald AR, Plummer FA, Kirui P, Bwayo JJ, Ngugi EN, Moses S, Temmerman M. Int J STD AIDS. 2000 Dec;11(12):804-11. PMID: 11138916

Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives. Kashiwada, Y, Chiyo J, Ikeshiro Y, Nagao T, Okabe H, Cosentino LM, Fowke K, Morris-Natschke SL, and Lee KH. Chem Pharm Bull (Tokyo) 2000, 48:1387 PMID:10993248

The HLA A2/6802 supertype is associated with reduced risk of perinatal human immunodeficiency virus type 1 transmission. MacDonald KS, Embree JE, Nagelkerke NJ, Castillo J, Ramhadin S, Njenga S, Oyug J, Ndinya-Achola J, Barber BH< Bwayo JJ, Plummer. J Infect Dis, 2001 Feb 1;183(3):503-6 . PMID:11133384

Apoptosis: A method of evaluating whole blood and peripheral blood mononuclear cell cryopreservation. J. Imm. Fowke KR, Behnke J, Hanson C, Shea K and Cosentino LM. Methods 2000, 244:139-44. PMID:11033026

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